The Effect of BMI and Type 2 Diabetes on Socioeconomic Status: A Two-Sample Multivariable Mendelian Randomization Study

OBJECTIVE To assess the independent causal effect of BMI and type 2 diabetes (T2D) on socioeconomic outcomes by applying two-sample Mendelian randomization (MR) analysis. RESEARCH DESIGN AND METHODS We performed univariable multivariable MR to jointly T2D outcomes. used overlapping genome-wide significant single nucleotide polymorphisms for as instrumental variables. Their impact household income regional deprivation was assessed using summary-level data from UK Biobank. RESULTS In analysis, higher related lower (marginal 1-SD increase in [? = ?0.092; 95% CI ?0.138; ?0.047]) (? 0.051; 0.022; 0.079). MR, controlling slightly deprivation. Diabetes not associated with these CONCLUSIONS High BMI, but diabetes, shows a link